Promethazine hydrochloride and codeine phosphate syrup is indicated for the short term aid of coughs and higher respiratory signs and symptoms associated with allergy or even the popular chilly.
While it can help many people, this medication provides a chance for abuse and should often bring about addiction. This possibility could possibly be bigger When you have a compound use ailment (like overuse of or addiction to medications/Liquor).
Promethazine hydrochloride takes place for a white to faint yellow, pretty much odorless, crystalline powder which slowly but surely oxidizes and turns blue on extended publicity to air.
Usually do not flush medicines down the toilet or pour them right into a drain Until instructed to do so. Thoroughly discard this merchandise when it's expired or no longer needed. Consult your pharmacist or area waste disposal firm.
The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory depression ensuing from opioid overdose. For clinically significant respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist shouldn't be administered within the absence of clinically substantial respiratory despair. Because the length of opioid reversal is anticipated to get a lot less than the period of action of codeine in Promethazine with Codeine Oral Remedy, very carefully keep track of the affected person till spontaneous respiration is reliably reestablished.
Discontinuation of a concomitantly used cytochrome P450 2D6 inhibitor could cause a lessen in codeine plasma focus and an increase in active metabolite morphine plasma concentration which could improve or prolong adverse reactions and may lead to most likely deadly respiratory melancholy.
Promethazine hydrochloride wasn't mutagenic during the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Indications and signs and symptoms of overdosage with promethazine range between gentle depression of your central nervous technique and cardiovascular method to profound hypotension, respiratory despair, unconsciousness and sudden Loss of life.
three) ], which could increase or prolong the two the therapeutic results and adverse reactions, and will lead to really serious respiratory despair. Stay clear of using Promethazine with Codeine Oral Alternative in patients who will be taking CYP3A4 inducers. If concomitant usage of a CYP3A4 inducer is important, Stick to the individual for decreased efficacy.
Never share opioid medicine with another man or woman, Particularly a person with a heritage of drug abuse or habit. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Maintain the medication in a spot wherever Many others can't get to it. Promoting or gifting away opioid medicine is against the law.
Utilization of PROMETHAZINE WITH CODEINE ORAL Remedy all through pregnancy can result in withdrawal signs or symptoms in your new child child that might be lifestyle-threatening Otherwise acknowledged and treated. Notify your healthcare service provider without delay In case you are Expecting or Consider you may well be pregnant.
If the signs and symptoms or health issues will not recuperate or whenever they turn out to be even worse, connect with your medical doctor. Will not share your more info medicine with Many others and do not just take any person else's drugs. This medication comes with an additional affected person simple fact sheet referred to as a Medication Guideline. Read through it with treatment. Read through it once again each time promethazine and codeine is refilled.
The diagnostic analysis of clients with this syndrome is intricate. In arriving in a analysis, it can be crucial to identify instances exactly where the clinical presentation consists of the two significant health care disease (e.
Tell clients that a household teaspoon isn't an precise measuring machine and this kind of use may lead to overdosage and critical adverse reactions [see OVERDOSAGE (ten)]. For prescriptions where by a measuring device just isn't presented, a pharmacist can offer an ideal calibrated measuring machine and can offer Guidance for measuring the proper dose.